UFC Fight Night 81: Dillashaw vs. Cruz was a mixed martial arts event held on January 17, 2016, at the TD Garden in Boston, Massachusetts. A UFC Bantamweight Championship bout between defending champion T.J. Dillashaw and former WEC and UFC Bantamweight champion Dominick Cruz headlined this event.

UFC Fight Night 81: Dillashaw vs. Cruz was a mixed martial arts event held on January 17, 2016, at the TD Garden in Boston, Massachusetts. A UFC Bantamweight Championship bout between defending champion T.J. Dillashaw and former WEC and UFC Bantamweight champion Dominick Cruz headlined this event.