Rookie FBI agent Jo Dee Foster has been assigned to work on the case of the Psycho Killer, a psycho killer who has psycho-killed over 120 people. But to learn more about the Psycho Killer, Jo is forced to meet Dr. Animal Cannibal Pizza, a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo's girlfriend Jane Wine has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel, so she and Jo can be happy, but gets lost in a horrible storm, caused mostly by a special effects crew behind her car, and stops at the Cemetery Motel, where the owner, Antonio Motel, is dominated by his insane mother.

Rookie FBI agent Jo Dee Foster has been assigned to work on the case of the Psycho Killer, a psycho killer who has psycho-killed over 120 people. But to learn more about the Psycho Killer, Jo is forced to meet Dr. Animal Cannibal Pizza, a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo's girlfriend Jane Wine has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel, so she and Jo can be happy, but gets lost in a horrible storm, caused mostly by a special effects crew behind her car, and stops at the Cemetery Motel, where the owner, Antonio Motel, is dominated by his insane mother.